Reporting MRONJ as an Adverse Drug Reaction: An Oral Surgery Survey

Abstract

Abstract Introduction Medication related osteonecrosis of the jaw (MRONJ) is a significant adverse drug reaction associated with anti-angiogenic and anti-resorptive medications. The aim of this survey was to establish the knowledge and understanding of the reporting of adverse drug reactions with a particular focus on MRONJ within the local department. Methodology An electronic survey was disseminated to dentists working in the Oral Surgery department within the Dental Division of Birmingham Community Healthcare Trust in November 2021. The survey consisted of 14 open and closed questions relating to the identification and reporting of MRONJ as an adverse drug reaction. Results Although 97% of participants had seen a patient with MRONJ, only 19% had reported an adverse drug reaction to any medication. Interestingly 27% of respondents felt that MRONJ should be classified as a ‘postoperative complication’ rather than an ‘adverse drug reaction’. 22% of participants were unaware of how to report an adverse drug reaction. Conclusion This survey acts as an important reminder to encourage both patients and dental professionals to consider reporting adverse drug reactions, including suspected MRONJ, to the MHRA. Reporting aids accurate national data collection, highlights risk and supports ongoing research in this area.