White Matter Hyperintensities and Cortical Atrophy are associated with Neuropsychiatric Symptoms in Neurodegenerative and Cerebrovascular Diseases
Author:
Ozzoude Miracle1, Varriano Brenda2, Beaton Derek3, Ramirez Joel4, Adamo Sabrina5, Holmes Melissa F.4, Scott Christopher J.M.4, Gao Fuqiang4, Sunderland Kelly M.6, McLaughlin Paula7, Goubran Maged8, Kwan Donna9, Roberts Angela10, Bartha Robert11, Symons Sean8, Tan Brian6, Swartz Richard H.4, Abrahao Agessandro4, Saposnik Gustavo3, Masellis Mario12, Lang Anthony E.13, Marras Connie13, Zinman Lorne4, Shoesmith Christen11, Borrie Michael11, Fischer Corinne E.3, Frank Andrew14, Freedman Morris6, Montero-Odasso Manuel11, Kumar Sanjeev15, Pasternak Stephen11, Strother Stephen C.6, Pollock Bruce G.15, Rajji Tarek K.15, Seitz Dallas16, Tang-Wai David F.17, Turnbull John18, Dowlatshahi Dar14, Hassan Ayman19, Casaubon Leanne8, Mandzia Jennifer11, Sahlas Demetrios18, Breen David P.20, Grimes David14, Jog Mandar11, Steeves Thomas D.L.3, Arnott Stephen R.6, Black Sandra E.12, Finger Elizabeth11, Rabin Jennifer4, Investigators ONDRI9, Tartaglia Maria Carmela13
Affiliation:
1. York University 2. Central Michigan University College of Medicine 3. St. Michael’s Hospital 4. Sunnybrook Health Sciences Centre 5. University of Toronto Scarborough 6. Rotman Research Institute of Baycrest Centre 7. Nova Scotia Health 8. University of Toronto 9. Queen’s University 10. Northwestern University 11. Western University 12. Sunnybrook Research Institute, Sunnybrook Health Sciences Centre 13. Movement Disorder Clinic, University Health Network 14. University of Ottawa Brain and Mind Research Institute and Ottawa Hospital Research Institute 15. Centre for Addiction and Mental Health 16. University of Calgary 17. Memory Clinic, University Health Network 18. McMaster University 19. Thunder Bay Regional Health Research Institute 20. University of Edinburgh
Abstract
Abstract
Background: Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities and brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution of white matter hyperintensities and cortical atrophy to NPS in participants across neurodegenerative and cerebrovascular diseases.
Methods: 513 participants with one of these conditions, i.e. Alzheimer’s Disease/Mild Cognitive Impairment, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Parkinson’s Disease, or Cerebrovascular Disease were included in the study. NPS were assessed using the Neuropsychiatric Inventory – Questionnaire and grouped into hyperactivity, psychotic, affective, and apathy subsyndromes. White matter hyperintensities were quantified using a semi-automatic segmentation technique and FreeSurfer cortical thickness was used to measure regional grey matter atrophy.
Results: Although NPS were frequent across the five disease groups, participants with Frontotemporal Dementia had the highest frequency of hyperactivity, apathy, and affective subsyndromes compared to other groups, whilst psychotic subsyndrome was high in both Frontotemporal Dementia and Parkinson’s Disease. Results from univariate and multivariate results showed that various predictors were associated with neuropsychiatric subsyndromes, especially cortical thickness in the inferior frontal, cingulate, and insula regions, sex(female), global cognition, and basal ganglia-thalamus white matter hyperintensities.
Conclusions: In participants with neurodegenerative and cerebrovascular diseases, our results suggest that increased cortical atrophy and white matter hyperintensities burden in several cortical-subcortical structures may contribute to the development of NPS. Further studies investigating the mechanisms that determine the progression of NPS in various neurodegenerative and cerebrovascular diseases are needed.
Publisher
Research Square Platform LLC
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