Dysregulation of Electrolyte Balance and Lipid Profile in Rats Following Oral Administration of Methanolic Fruit Pulp Extract of Azanza garckeana (Tula Kola Nut)

Author:

Farrau Usman1ORCID,Dawud Fatimah Alhassan1,Abdulkadir Teslim Simisola1,Augustine Banlibo Dubo1,Jaafar Aliyu1,Egbunu Victor Ugbede-ojo1,Hinmikaye Victor Oluwafemi1,Adebayo Sodiq Abiodun1,Salman Maryam1

Affiliation:

1. Ahmadu Bello University Zaria-Nigeria

Abstract

Abstract

This study investigated the effects of methanolic fruit pulp extract of Azanza garckeana(MFEAG) on renal function through acute and subacute toxicity studies. Twenty-nine (29) apparently healthy adult male Wistar rats weighing 100-120 grams were used. For the acute study, 9 rats were randomly grouped into three: Group 1 were administered 300 mg/kg MFEAG once. Group 2 was sequentially administrated the next dose of 2,000 mg/kg, also once, when there were no signs of toxicity or mortality in Group 1 48 hours post-treatment, while Group 3 were administered the vehicle (10% v/v Tween 80). The rats were then observed for two weeks, and then sacrificed. For the subacute study, 20 rats were randomly grouped into four and daily administered once with the extract (at 300, 600, and 1,200 mg/kg doses) and the vehicle, respectively, for four weeks. No significant effects were observed on serum kidney function markers of the treated rats, except for the level of serum chloride that was increased and that of serum triglyceride that was decreased after the acute study, and then the serum sodium that was increased after the subacute study. These findings indicate that MFEAG may cause some level of impairment in renal function.

Publisher

Research Square Platform LLC

Reference64 articles.

1. Lamien-Meda A, Lamien CE, Compaore MM, Meda RN, Kiendrebeogo M, Zeba B, Millogo JF, Nacoulma OG (2008) Molecules 13:581

2. Woo CSJ, Lau JSH, El-Nezami H (2012) Adv Bot Res 62:365

3. Tolu A, Mocan A, Vlase L, Parvu AE, Vodnar AC, Gheldiu AM, Moldovan C, Oniga L (2018) Front Pharmacol 9:1

4. Ahmad Khan MS, Ahmad I (2018) New Look to Phytomedicine Adv Herb Prod as Nov Drug Leads. Elsevier Inc., pp 3–13

5. Ardalan M-R, Rafielan-Kopaei M (2013) J Nephropharmacology 2:11

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3