Parathyroid hormone related peptide levels may be related to obesity: a novel target for treatment?

Abstract

Abstract Obesity, has become a significant public health issue in the last two decades In recent years, several studies have suggested that adipose tissue homeostasis is vital in developing obesity. The production of excessive pro-inflammatory adipokines and inflammatory chemokines by dysfunctional adipocytes contributes to chronic inflammation and ultimately leads to systemic metabolic problems The Parathyroid Hormone-Related Protein (PTHrP), a member of a small gene family associated with parathyroid hormone was shown to increase cachexia by browning white adipose tissue. Along with the role of brown adipose tissue in obesity prevention, PTHrP may have a role in the etiology of obesity. This study aims to evaluate the probable relationship between obesity, PTHrp, and inflammation. Material and methods Patients who were admitted to hospital for bariatric surgery were included in this cross-sectional study. For biochemical tests the venous blood of patients fasted for 12-14 h was taken in the morning. PTHrP elisa kit: Human Parathyroid Hormone Related Protein ELISA Kit (Cat.No: MBS017831).used for PTHrP measurements following the manufacturer’s instructions. Results A total of 550 patients were recruited for the study, of which 145(26.4%) were males. mean BMI was 40.88±5.85 kg/m2 and mean PTHrP was 35.43±12.83. The patient group was grouped in terms of BMI (Group 1= BMI<40 and Group 2 =BMI≥40). CRP was significantly higher in group 2(4.8±3.3 vs 4.1±2.9; P=0.004) while PTHRP was significantly lower in (36.19±11.87vs. 36.896±13.577; P=0.005). ın correlation analysis BMI was found to be positively correlated with CRP(R=0.341, P=0.00), blood glucose(R=0.091, P=0.034) and negatively correlated with PTHRP(R=-0.134, P=0.002). ın linear regression, PTHrP, CRP and blood glucose were major determinants of BMI Conclusion A lower BMI was associated with a higher PTHrP level. PTHrP, may cause a transformation from brown to white adipose tissue. Therefore, PTHrP might be a novel treatment for overweight persons.