Predictors of Clinical Cure and off-treatment HBsAg Reversion in Patients with Chronic Hepatitis B receiving Peg-interferon-α-based Therapy

Author:

Liu Zhongwei1,Liu Ming1,Gong Hongmei1,Li MaoShi2,Wang Jing1,Tan Zhaoxia1,Wu Yi1,Yang Yanlin3,Deng Ying4,Mao Qing1

Affiliation:

1. Southwest Hospital, Third Military Medical University (Army Medical University

2. The General Hospital of PLA Tibet Military Area Command

3. 78th Group Military Hospital of the People’s Liberation Army of China

4. Yubei District People’s Hospital

Abstract

Abstract Background Currently, pegylated interferon-α (Peg-IFN-α)-based antiviral therapy brings dawn to the clinical cure of chronic hepatitis B(CHB). Our aim was to investigate markers associated with clinical cure and off-treatment hepatitis B surface antigen (HBsAg) reversion in CHB receiving Peg-IFN-α-based therapy. Methods In total, 101 patients with hepatitis B e antigen-negative CHB who were treatment-naive or nucleotide analogs(NAs) treated patients were enrolled, then they were all received Peg-IFN-α-based therapy. Hepatitis B core-related antigen (HBcrAg), HBsAg and hepatitis B surface antibody (HBsAb) levels were examined dynamically and used to investigate the predictive value for HBsAg clearance and off-treatment reversion. Results Out of 101 patients, 41(40.59%) individuals achieved HBsAg clearance at the end of treatment (EOT). High baseline HBsAg (2.32 log10 IU/mL) combined with HBcrAg (3.90 log10 U/mL) was strongly associated with the HBsAg clearance (AUC = 0.714, P<0.001). The HBcrAg and HBsAg decline from baseline to week 12 showed good ability to predict HBsAg clearance (AUC = 0.807, P<0.001), while the HBsAg decline from week 12 to 24 were associated with HBsAg clearance (AUC = 0.745, P<0.001). A combination of HBcrAg < 3.80 log10 U/mL and HBsAb ≥ 51.50 IU/L at EOT had a negative predictive value of 85.71% for off-treatment HBsAg reversion (AUC = 0.840, P < 0.001). Conclusions HBcrAg and HBsAg can be used to predict clinical cure, while the HBcrAg and HBsAb were closely related to the off-treatment HBsAg reversion in patients with CHB receiving Peg-IFN-α-based therapy.

Publisher

Research Square Platform LLC

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