Affiliation:
1. the First Affiliated Hospital of Guangzhou Medical University
2. Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)
Abstract
Abstract
Objective:
The objective of this study was to determine whether neoadjuvant immunochemotherapy impacted the subsequent surgical or pathological outcomes of patients with pulmonary lymphoepithelioma-like carcinoma (PLELC). Thisstudy was designed to evaluate the safety and efficacy of neoadjuvant immunochemotherapy in PLELC patients.
Methods:
A retrospective study was conducted on patients who received neoadjuvant immunochemotherapy in combination with chemotherapy followed by surgery between 2019 and 2022. The clinical records of the patients were analyzed.
Results:
Out of the 31 patients with PLELC who underwent neoadjuvant therapy followed by surgery, 18 patients (58.0%) experienced downstaging of the tumor. Nineteen patients (61.5%) achieved a partial response, 2 patients (6.4%) achieved a complete response,and 2 (6.4%) had progressive disease. Pathological evaluation of resected specimens revealed that 10 (32.3%) patients achieved major pathological response (MPR), including 2 (6.4%) who achieved complete response (CR). The mean disease-free survival (DFS) was 17.4 months, which was not significantly different from the value in LUSQ patients (15.1 months).
Conclusion:
Neoadjuvant immunochemotherapy resulted in downstaging of the tumor, thereby rendering it resectable, and did not significantly affect the safety and feasibility of surgery in this patient cohort.
Publisher
Research Square Platform LLC