Association of diet and sunshine exposure with inflammatory bowel disease: a multicentered case-control study using propensity matching analysis in China-Reference-Cited by-同舟云学术

Association of diet and sunshine exposure with inflammatory bowel disease: a multicentered case-control study using propensity matching analysis in China

Published:2023-09-22 Issue: Volume: Page:
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Author:

Chu Xiaotian¹,Chen Xuanfu¹,Zhang Huimin¹,Wang Yufang²,Guo Hong³,Chen Yan⁴,Liu Xiaowei⁵,Zhu Zhenhua⁶,He Yao⁷,Ding Xueli⁸,Wang Qunying⁹,Zheng Changqing¹⁰,Cao Xiaocang¹¹,Yang Hong¹,Qian Jiaming¹

Affiliation:

1. Chinese Academy of Medical Sciences & Peking Union Medical College

2. Sichuan University West China Hospital

3. Chongqing General Hospital

4. Second Affiliated Hospital of Zhejiang University

5. the First Xiangya Hospital, Central South University

6. the First Affiliated Hospital of Nanchang University

7. First Affiliated Hospital of Sun Yat-sen University

8. the Affiliated Hospital of Qingdao University

9. Jinhua Hospital of Zhejiang University

10. Sheng Jing Hospital

11. Tianjin Medical University General Hospital

Abstract

Abstract The association of inflammatory bowel diseases (IBD) emergence and several environmental factors remained unclear, especially in Chinese. The aim is to explore the association of different environmental factors with IBD risk. This is a multicentered case-control study including 11 hospitals from 11 cities in China. Totally 1230 subjects were enrolled consecutively. IBD patients and healthy controls (HC) were matched at a 1:1 ratio using propensity-score matching (PSM) with a caliper value of 0.02. Questionnaires of different environmental factors were collected. In multivariate conditional logistics regression analyses, for both CD and UC, proper amount of alcohol and milk consumption, and fresh fruit every day were protective factors, while egg and chocolate were risk factors. Sunshine exposure for over 25% of a day was a protective factor only in CD. In eastern regions of China, CD patients tended to consume more egg and have less sunshine exposure and UC patients had more chocolate. IBD patients from urban regions or with higher per capita monthly income consumed more fruit, egg and chocolate. The difference in diet of different population highlights the importance of a balanced diet and different prevention strategy in different regions.

Publisher

Research Square Platform LLC

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