Association Between the miR-100 rs1834306 A>G SNP and Susceptibility to Vascular Malformation in Southern Chinese Children

Abstract

Abstract Background:Vascular malformation was related to genes and resulted in functional and morphologic anomalies. Genetic variations affecting development of vessel endothelial cells are unclear. Therefore, this study aimed to investigated the potential value of miR-100 rs1834306 A>G SNP as a marker of susceptibility to vascular malformation. Methods:In this case–control study in southern Chinese children, we collected samples from 1158 controls and 1113 patients with vascular malformation. TaqMan genotyping of miR-100 rs1834306 A>G was performed by real-time fluorescent quantitative polymerase chain reaction. Result:Multivariate logistic regression analysis showed that there was no significant association between the presence of the miR-100 rs1834306 A>G polymorphism and susceptibility to vascular malformation by evaluating the values of pooled odds ratios and 95% confidence intervals. Similarly, among different sites, rs1834306 A>G was also not associated with vascular malformation. Conclusion:Our results suggest that the miR-100 rs1834306 A>G polymorphism is not associated with susceptibility to vascular malformation in southern Chinese children. These results need to be further confirmed by investigating a more diverse ethnic population of patients with vascular malformation.