Affiliation:
1. Bengbu Medical College
2. Anhui Center for Disease Control and Prevention
Abstract
Abstract
Background
To explore differences in epidemiology, initial clinical characteristics, routine blood and physiological and biochemical indices between Severe fever with thrombocytopenia syndrome (SFTS) and scrub typhus(ST) patients with the aim of providing evidence for early diagnosis and treatment.
Methods
Between February and November 2022, a total of 122 cases of SFTS and 22 cases of ST were confirmed in the laboratory of hospitals in the provinces of Hefei, Anqing and Liuan, Anhui.
Results
The early clinical features showed that headache, generalized pain, cutaneous petechiae and ecchymosis, loss of appetite, skin rash, and specific crusts and ulcers were more pronounced in ST patients compared with SFTS patients, and only diarrhoea was more pronounced in SFTS patients compared to ST patients and the difference was found to be statistically significant (P < 0.05). Blood regular indexes showed that the WBC, LYMPH, MONO, NEUT, and PLT counts were significantly reduced in SFTS patients as compared to the ST patients, and all were below the normal range in the SFTS group, while ST all fell within normal ranges, and the differences were all found to be statistically significant (P < 0.05). However,WBC, LYMPH and P-LCR were within normal values. Physiologic and biochemical results showed that SFTS patients had lower TBIL, IBIL, ALT, Ga+, BUN, CREA, CRP, PCT, TT, PT, and TNR counts than ST patients. CK, CK-MB, LDH, UA and AG were significantly higher in SFTS patients compared to ST patients and the differences were found to be statistically significant (P < 0.05). However, TBIL, IBIL, CK-MB, Ca2+ counts were in the normal range in both groups.
Conclusion
Diarrhea was more pronounced and myocardial injury was more severe in SFTS patients, while scab or ulcer disease, impaired liver and kidney function, and inflammatory response were more pronounced in ST patients.
Publisher
Research Square Platform LLC
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