Affiliation:
1. Department of Laser Medicine, the First Medical Centre, Chinese PLA General Hospital
2. Medical School of Chinese PLA
3. Medical Big Data Center, Chinese PLA General Hospital
Abstract
Abstract
Objective. To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN).
Methods. We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec. 2019 in Chinese PLA general hospital. Patients’ outcomes were compared according to the HPV genotyping, cytological tests within 3–6-month follow-up post-treatment, the pathological examination would be performed if the cytological results indicated the risk of CIN. Propensity score matching (PSM) was adapted to pair the baseline. Complete remission (CR), partial remission (PR) and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP.
Results. In total, 30 pairs were matched as the matching tolerance was set as 0.03. No significant difference in CR and PR was found between the 5-ALA PDT and LEEP groups (73.33% vs 84.00%, P=0.340; 3.33% vs 4.00%, P=1.000). Among different CIN group, no statistically significant difference was found between 5-ALA PDT and LEEP. Moreover, in terms of HPV remission rate, 5-ALA PDT showed the same efficacy as LEEP (59.26% vs 53.85%, P=0.691).
Conclusions.Overall, topical 5-ALA PDT for cervical lesions is generally regarded as a non-invasive and repeatable procedure that is considered safe with minimal side effects while preserving the cervical structure. Moreover, it has been observed that in many cases, PDT with 5-ALA achieves successful treatment outcomes that are comparable to those of LEEP.
Publisher
Research Square Platform LLC
Reference32 articles.
1. JF S, K C, cancer QYJIjo. Burd Cerv cancer China: synthesis Evid. 2012;130(3):641–52.
2. The epidemiology of human papillomavirus infections;Virology JGB,2005
3. Productive Lifecycle of Human Papillomaviruses that Depends Upon Squamous Epithelial Differentiation;Kajitani N;Front Microbiol,2012
4. Efficacy of 5-aminolevulinic acid and LED photodynamic therapy in cervical intraepithelial neoplasia: A clinical trial. Photodiagnosis and photodynamic therapy;Mizuno M
5. Clearance of human papillomavirus infection after successful conization in patients with cervical intraepithelial neoplasia;Kim YT;Int J Cancer 2010 Apr