Prevalence in Varicella Zoster Virus DNA in Inflammatory Bowel Disease Patients

Abstract

Abstract Individuals with an Inflammatory-bowel-disease are at a higher risk of contracting the virus. The prevalence of VZV in IBD patient’s is a particularly concerning, as it has been-reported to be highly contagious, severe, and in some cases fatal in patients with colitis. This study was aim to be evaluate the prevalence of VZV in individuals with IBD. Methods: Serum and biopsy-sample of large-intestine specimens from patients with IBD (Ulcerative-Colitis-(n = 31), patients with Crohn’s-disease-(n = 23)) and control group of non-IBD-(n = 21) were analysed the anti-VZV-IgG presence from done by ELISA and Viral-DNA of VZV by Nested-PCR. All biopsy-samples were viral VZV-DNA was analysed done by using Nested-PCR assay. In this study, a statistical-model was used to compare prevalence of the virus in IBD-patient and non-IBD patients. Results: all IBD-case patients, 47 and 09 were positive for serum of anti-VZV Antibodies by ELISA and tissue-Biopsy of VZV-DNA by nested PCR, and to non-IBD control group,19 and 00 were positive for serum of anti-VZV Antibodies by ELISA and Tissue-Biopsy of VZV-DNA by Nested-PCR-Method. Analyses of nested-PCR of results showed in a robust correlation in between VZV prevalence and Inflammatory-bowel-disease. Conclusion: The detection of VZV in routine samples might be an indicator for the inclusion of the vaccine for VZV in the childhood immunization-program has been proposed, Whereas the VZV-vaccine is widely available, and as the vaccine has been quite effective in preventing the complications associated with VZV infection.