Affiliation:
1. United Arab Emirates Uni
Abstract
Abstract
Background
Precision medicine, targeting treatments to individual genetic and clinical profiles, faces challenges in data collection, costs, and privacy. Generative AI offers a promising solution by creating realistic, privacy-preserving patient data, potentially revolutionizing patient-centric healthcare.
Objective
This review examines the role of deep generative models (DGMs) in clinical informatics, medical imaging, bioinformatics, and early diagnostics, showcasing their impact on precision medicine.
Methods
Adhering to PRISMA guidelines, the review analyzes studies from databases such as Scopus and PubMed, focusing on AI's impact in precision medicine and DGMs' applications in synthetic data generation.
Results
DGMs, particularly Generative Adversarial Networks (GANs), have improved synthetic data generation, enhancing accuracy and privacy. However, limitations exist, especially in the accuracy of foundation models like Large Language Models (LLMs) in digital diagnostics.
Conclusion
Overcoming data scarcity and ensuring realistic, privacy-safe synthetic data generation are crucial for advancing personalized medicine. Further development of LLMs is essential for improving diagnostic precision. The application of generative AI in personalized medicine is emerging, highlighting the need for more interdisciplinary research to advance this field.
Publisher
Research Square Platform LLC
Reference61 articles.
1. Multi-omics data integration by generative adversarial network;Ahmed KT;Bioinformatics,2022
2. Ahuja Y, Zou Y, Verma A, Buckeridge D, Li Y (2022) MixEHR-Guided: A guided multi-modal topic modeling approach for large-scale automatic phenotyping using the electronic health record. JournalofBiomedicalInformatics, 134. https://doi.org/10.1016/j.jbi.2022.104190
3. Ali M, Aittokallio T (2019) Machine learning and feature selection for drug response prediction in precision oncology applications. In BiophysicalReviews (Vol. 11, Issue 1). https://doi.org/10.1007/s12551-018-0446-z
4. Balla Y, Tirunagari S, Windridge D (n.d.). PediatricsinArtificialIntelligenceEra:ASystematicReviewonChallenges,Opportunities,andExplainability. https://github.com/
5. Bao J, Chen D, Wen F, Li H, Hua G (2017) CVAE-GAN: Fine-Grained Image Generation through Asymmetric Training. ProceedingsoftheIEEEInternationalConferenceonComputerVision, 2017-October. https://doi.org/10.1109/ICCV.2017.299