The effects of two high-intensity interval training protocols on serum levels of Glypican-4 in an overweight and obese female population.

Abstract

Abstract Objectives: The purpose of this study was to investigate the effects of two high intensity training protocols on serum levels of, Glypican-4 in overweight and obese women. Design, Methods: Thirty-seven overweight and obese females were randomized into three groups, a HIIT (n=12), HICT (n=12) and a control group (n=13). The training groups performed three training sessions per week for a duration of ten weeks. Anthropometric measurements and blood samples were collected at baseline and following ten weeks of training. Statistical analysis was performed using SPSS version 26. Results: Post ten weeks training, glypican-4 concentration (HIIT: p=.015, HICT: p=.014) HOMA-IR (p<0.001), fasting glucose (p<0.001), fasting insulin (HIIT: p=.015, HICT: P=.037), body weight (p<0.001), body mass index (p=0.001), body fat percentage (p<0.001), FM (p <0.001), WC (p<0.001), WHR (p< 0.001) significantly decreased in the training groups when compared with baseline values. These variables also significantly decreased in the training groups when compared to the control group (p<0.05). There was also a significant group x time interaction effects observed during the analysis, and decreases were also noted when comparisons with the control group were made. Conclusions: The findings suggest that both HIIT and HICT exercise training protocols effectively decrease glypican-4 concentrations while improving anthropometric profiles in overweight and obese females.