Simplified calculation method of ICG based on LDY

Abstract

Abstract Background: Liver cancer has one of the highest death rates in the world. Hepatectomy is the most important treatment for liver cancer. Preoperative evaluation of hepatic reserve is required to determine whether hepatectomy is feasible. Indocyanine green (ICG) clearance assay is an effective way to assess liver function prior to hepatectomy. However, due to its high cost and adverse reactions in some patients, we need to find a noninvasive method equivalent to the ICG clearance test. Methods: We retrospectively analyzed 650 clinical data to explore the risk factors that affect liver reserve function. Logistic regression model was established by SPSS, and linear regression was established an equivalent formula for predicting the ICG 15-minute retention rate. Result: We found that spleen volume and the LDY were independent risk factors for the ICG 15-minute retention rate and found a linear correlation between spleen volume and the LDY. Finally, the formula was obtained: LN(Y(ICG-R15))=3.466+0.045X1(LDY)-0.066X2(ALB)-0.002X3(Cr)-0.002X4(PLT)+0.007X6(TBIL)+0.116X7(PT),R20.395. The area under the ROC curve (AUC) was 0.83 for ICG-R15≥10%. The accuracy was 86%. Conclusions: We have found that spleen volume is an independent risk factor for the ICG 15-minute retention rate and can simplify the prediction of liver reserve function through LDY.