Preoperative serum selenium predicts acute kidney injury after adult cardiac surgery

Abstract

Abstract Background: The relationship between serum selenium (Se) and acute kidney injury after adult cardiac surgery remains controversial. This study aimed to investigate the association of preoperative Se level with incident CSA-AKI. Method and Results: A retrospective cohort study was conducted on patients who underwent cardiac surgery. The primary outcome was incident CSA-AKI. Multivariable logistic regression models and natural cubic splines were used to estimate the association of Se levels and primary outcome. A total of 453 patient with a mean age of 62.97 years were included. Among all patients, 159 (35.1%) incident cases of CSA-AKI were identified. The level of preoperative Se concentration in patients with CSA-AKI was significant lower than that in patients without CSA-AKI. In comparison with patients in the lowest quartile, those with the highest quartile were associated with lower risk of CSA-AKI [adjusted OR (95% CI): 0.61(0.40-0.95)]. Dose-response relationship curve revealed a nearly L-shape correlation between serum Se selenium levels and incident CSA-AKI. Conclusion: Our study suggested that a higher level of serum Se was significantly associated with lower risk of CSA-AKI. Further prospective studies are needed to clarify the causal relationship between serum Se level and incident CSA-AKI.