Vortioxetine alleviates PTSD-like behaviors by regulating ABPs through up-regulating FMRP in the hippocampus of rats exposed to SPS

Abstract

Abstract Posttraumatic stress disorder (PTSD) is a mental disorder that may lead to a series of changes in the central nervous system, including damage to synaptic plasticity, loss of neuronal dendritic spine, increased apoptosis or inflammation. However, the pathogenesis of PTSD is still unclear and there are few efficacious pharmacological treatments for PTSD. In the present study, we found that intraperitoneal injection of vortioxetine could alleviate PTSD-like behaviors including depression-like behavior and fear memory extinction disorder of rats exposed tosingle-prolonged stress (SPS). This effect might be related to the upregulation of FMRP in the hippocampus of SPS rats. Furthermore, vortioxetine could also increase the dendritic spine density and the expression of synapse-related proteins, including PSD95 and synapsin I and Actin-binding proteins (ABPs), such as drebrin1, profilin2 and p-cofilin1 in hippocampal cell of rats exposed to SPS. The results of this study indicated that vortioxetine might alleviate PTSD-like behaviors by regulating neuronal morphology in the hippocampus of rats exposed to SPS through regulating FMRP, which might be related to the regulation of synapse-related proteins and ABPs.