Implementation of triply periodic minimal surface (TPMS) structure in mesenchymal stem cell differentiation.

Abstract

Abstract Tissue engineers have recently been interested in triply periodic minimum surfaces (TPMSs) for use in creating biomimetic porous scaffolds. Improved cell attachment, migration, and proliferation may be achieved with TPMS scaffolds because of its many benefits, such as a high volume to surface area ratio, reduced stress concentration, and enhanced permeability compared to conventional lattice architectures. Some of the crucial tissue-specific parameters, such permeability, Elastic modulus, and pore size, have been considered by the designers of various TPMS scaffolds described in the literature. These days, triply periodic minimum surface (TPMS) is seen as a leading option for building porous structures due to its smooth edges, fully integrated porous architectures, and mathematically adjustable geometry. Many benefits of TPMS, however, are not being properly used in ongoing studies. This study suggests the future direction of the TMPS in the perspective of the mesenchymal stem cell differentiation to overcome many shortcoming which was faced by the researchers.