Affiliation:
1. Guizhou University of Traditional Chinese Medicine
2. Inspection Center of Guizhou Drug Administration
Abstract
Abstract
Backgrounds:Low back pain (LBP) is one of the leading cause of health function loss worldwide.There has been ongoing controversy regarding whether vitamin D deficiency can cause lower back pain.This study assessed the impact of 25-OH-D on LBP using Mendelian Randomization.
Methods:Using GWAS databases, the exposure variable was set as 25-OH-D, and the outcome as low back pain. IVW, MR-Egger Regression, Simple Median, Weighted Median, and Weighted Mode methods were applied to assess the impact of 25-OH-D on low back pain.
Results: IVW analysis revealed no causal relationship between 25-OH-D and low back pain (OR = 1.14, 95% CI: 0.95-1.38, P = 0.165). The MR-Egger intercept test (P >0.05) did not detect pleiotropic effects, indicating robust causal inference using Mendelian Randomization.
Conclusion: No causal relationship between serum levels of 25-OH-D and low back pain was identified by MR analysis.
Publisher
Research Square Platform LLC
Reference28 articles.
1. Vitamin D levels in relation to low back pain during adolescence;Al-Taiar A;British Journal of Nutrition,2020
2. High Prevalence of Hypovitaminosis D in Patients with Low Back Pain: Evidence from Meta-Analysis;Bansal D;Pain Physician,2018
3. Evaluation of vitamin D levels in patients with chronic low back-leg pain;Çalık Y;Acta Orthopaedica et Traumatologica Turcica,2017
4. 25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts;Çolak Y;Clinical Chemistry,2020
5. Cui, A., Xiao, P., Fan, Z., Lei, J., Han, S., Zhang, D., Wei, X., Wang, P., & Zhuang, Y. (2023). Causal association of NAFLD with osteoporosis, fracture and falling risk: a bidirectional Mendelian randomization study. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1215790