Rosai-Dorfman's Disease start with Retroperitoneal Fibrosis and involving Pituitary Gland, Ocular Region: A Case Report

Abstract

Abstract Rosai-Dorfman's Disease (RDD) is a rare benign lymphoid tissue proliferative disease[1], and it may be associated with infection or immune dysfunction. The disease mostly occurs in the lymph nodes, and there are also clinical reports of multi-organ involvement in the central nervous system, nasopharynx, breast, eye socket, eyelid, thymus, centrum, upper airways and testes[2-5]. In previous literature reports, we had found that the disease can have two organs involved at the same time [6]. However, like in our case, the three organs (Cranial, Eyes, Peritoneum) involved simultaneously and the onset of retroperitoneal fibrosis was more than rare. Through this case, we could get one lesson: when a patient presents with retroperitoneal fibrosis firstly, and combined with Pituitary Gland, Ocular Region involvement, or when one disease alone cannot illustrate all the symptoms, we need to look for any other possible causes, the RDD must be taken into account. The clinical significance is that similar cases should be examined or even biopsy as soon as possible, so that patients can get treatment at the first time. Finally, we hope that the case descriptions will improve understanding of RDD for clinicians.