Affiliation:
1. Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine 1, Nanjing Drum Tower Hospital, Nanjing University 2
Abstract
Abstract
Background
Prolonged postoperative ileus (PPOI) is one of the common complication postoperative complications of gastric cancer (GC) surgery, with limited preventive and treatment options currently available. This study aims to investigate the therapeutic efficacy of sodium aescinate in managing PPOI and identifying the related risk factors of PPOI in GC patients.
Methods
A total of 121 patients with advanced GC were enrolled and assigned to two groups to receive sodium aescinate or no treatment. Univariate and multivariate analyses were used to identify the PPOI-related risk factors in postoperative GC patients.
Results
The study revealed that postoperative sodium aescinate treatment independently served as a protective factor against PPOI (OR = 0.25, CI: 0.07–0.86, P = 0.028). Furthermore, the incidence of PPOI was significantly lower in patients who received sodium aescinate treatment compared to those who did not (15/66 VS 4/55, P = 0.020).
Conclusions
Postoperative administration of sodium aescinate reduces the occurrence of PPOI in patients with advanced GC.
Publisher
Research Square Platform LLC
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