Developing a Novel Immune-Related two-Gene Signature and Immune Infiltration Pattern in Patients with psoriasis and chronic kidney disease

Abstract

Abstract Individuals with severe psoriasis (Ps) are at increased risk of developing chronic kidney disease (CKD), and conversely, CKD may contribute to the development of Ps. However, despite such an association between Ps and CKD, this relationship has not been fully elucidated. Therefore, there is a need for an in-depth study of the interactions between biomolecules and immunomarkers, as such associations may form the basis for identifying reliable diagnostic and monitoring methods for the disease. The goal of this study was to explore the potential relationship between Ps and biomarkers associated with CKD risk. First, we identified 74 common genes shared between Ps and CKD. These genes showed common transcriptional profiles in patients with Ps and CKD, and further functional analyses highlighted the key roles of inflammatory activation and innate immune response in the development of Ps and CKD. In addition, PPI networks and modules were constructed based on these genes, and four hub genes were screened using seven topological algorithms. Further analyses revealed altered immune responses common to patients with Ps and CKD. We identified two core immune-related genes (HIRGs), MX1 and DDX58, which were positively associated with macrophage and mast cell changes. Single-cell analysis revealed significantly increased expression of MX1 and DDX58 in T cells from patients with Ps and CKD. MX1 and DDX58 are involved in regulating the immune microenvironment and may induce inflammatory responses and immune dysfunction through T cell activation, which ultimately leads to the development of Ps and CKD. These two pivotal genes, MX1 and DDX58, may provide a new direction for breakthroughs in the clinical diagnosis and treatment of Ps combined with CKD.