The relationship between the occurrence of asthma and diabetes among a sample of patients attending Damascus Hospital

Abstract

Abstract Introduction: Diabetes is a major public health problem, and there is a continuing increase in the incidence and long-term complications. These complications are mainly sequelae of microvascular destruction in target organs. Many lung injuries occur in the context of diabetes due to the presence of abundant microcirculation and abundance of tissues. Macrophages, raising the possibility that lung tissue is a target organ in patients with diabetes. Research objectives: This research was designed to study the effect of diabetes, both the duration of infection with this disease, and control of diabetic status on lung function and the incidence of asthma. Methods and materials: A cross-sectional study, conducted on 100 diabetic patients attending Damascus Hospital in the period between 1/1/20217 and 1/1/2023. It was compared with a control group consisting of 100 healthy individuals without diabetes. It was recorded. Hemoglobin, fasting blood sugar, and a lung function test (spirometry) were measured for all participants in the study, and the following lung measurements were taken: maximum expiratory volume in the first second (FEV1), forced vital capacity (FVC), ratio (FEV1/FVC). Analyze the results using: mean + standard deviation, Pearson's chi-square, Pearson's correlation coefficient, and ANOVA test. Results The average percentage of expected FEV1 and expected FVC in people with diabetes is lower compared to healthy non-diabetic controls (p smaller than 0.05), and these values were lower in patients without controlled blood sugar compared to patients with controlled blood sugar, and the values were also lower in patients with diabetes for a longer period of time, these values were lower in patients with type 1 diabetes, and all previous criteria led to the occurrence of asthma. Conclusion The findings in this study suggest that the lung is a target organ for diabetes, and that diabetic patients have a decline in lung function and the incidence of asthma compared to non-diabetics in a blockade lesion model. Lung function deteriorates the longer the duration of diabetes and the longer the diabetes is uncontrolled.