Association of NFKB1 gene polymorphism (rs28362491)with cardiometabolic risk factor in patients undergoing coronary angiography

Abstract

Abstract Background: In the world, the main cause of mortality and morbidity is cardiovascular diseases (CVDs). Genetic and environmental factors are involved in the pathogenesis of diseases. Recently, reports have indicated that the NFKB1 gene rs28362491 is a functional polymorphism. The aim of the study was to investigate between the genotype of the NFKB1 gene and the cardiometabolic risk factor in patients undergoing coronary angiography. Methods and materials: This cross-sectional study was conducted on 462 patients who referred to Afshar Hospital for coronary angiography in 2021-2022. The polymerase chain reaction restriction fragment length polymorphism method was used to detect the genotype of rs28362491. Biochemical parameters were measured using commercial kits. Gensini and Syntax scores were calculated using the angiography result to assess the extent of coronary artery stenosis. Multivariate logistic regression analysis was used to study between cardiometabolic risk factors and genotype variants. Results: The frequencies of the ins/ins, ins/del and del/del genotypes were 31.7%, 52.9% and 18.5%, respectively. Variant genotypes were not associated with the likelihood of having abnormally high serum alanine aminotransferase (ALT) (p-value = 0.51), aspartate aminotransferase (AST) (p-value = 0.99), Gensini score (p-value = 0.48) and syntax score (p-value = 0.74) in the crude model even after adjustment for confounding factors. There was no association between NFKB1 gene genotypes and possible hypertension and lipid profile. Conclusion: The ATTG polymorphism was not associated with cardiometabolic risk factors in the patients undergoing coronary angiography. Further investigations are needed to assess the association between variants of 28362491 and cardiometabolic markers.