Benzocaine-N-acylindoline Conjugates: Synthesis and Antiviral Activity Against Coxsackievirus B3-Reference-Cited by-同舟云学术

Benzocaine-N-acylindoline Conjugates: Synthesis and Antiviral Activity Against Coxsackievirus B3

Published:2023-10-30 Issue: Volume: Page:
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Author:

Volobueva Alexandrina¹,Shetnev Anton²^ORCID,Mikhalski Mikhail¹,Panova Valeria³,Barkhatova Darina⁴,Korshunova Ekaterina³,Ivanovskii Sergey⁵,Zarubaev Vladimir¹,Baykov Sergey⁴

Affiliation:

1. Saint-Petersburg Pasteur Institute: Sankt-Peterburgskij naucno-issledovatel'skij institut epidemiologii i mikrobiologii imeni Pastera

2. MFTI: Moskovskij fiziko-tehniceskij institut nacional'nyj issledovatel'skij universitet

3. Yaroslavl State Pedagogical University named after K.D. Ushinsky

4. Saint-Petersburg State University: Sankt-peterburgskij gosudarstvennyj universitet

5. Yaroslavl State Pedagogical University named after K.D. Ushinky

Abstract

Abstract Indoline-5-sulfonamide derivatives of benzocaine have been synthesized using a sequence of three reactions: N-acylation, sulfochlorination, and sulfamidation, and their antienteroviral activity has been evaluated. Two compounds, namely, ethyl 4-((1-(cyclobutanecarbonyl)indoline)-5-sulfonamido)benzoate and ethyl 4-((1-benzoylindoline)-5-sulfonamido)benzoate exhibited a medium level of activity against coxsackievirus B3 (Nancy strain) in vitro. Their antiviral potential is exerted upon prophylactic application when added to cell culture before infection with the virus.

Publisher

Research Square Platform LLC

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