Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study-Reference-Cited by-同舟云学术

Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study

Published:2023-09-28 Issue: Volume: Page:
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Author:

Nickl-Jockschat Thomas¹^ORCID,Sharkey Rachel¹,Bacon Chelsea¹,Peterson Zeru²^ORCID,Rootes-Murdy Kelly,Salvador Raymond,Pomarol Edith,Karuk Andriana,Homan Philipp³^ORCID,Ji Ellen³,Omlor Wolfgang³,Homan Stephanie⁴,Georgiadis Foivos³,Kaiser Stefan,Kirschner Matthias^ORCID,Ehrlich Stefan,Dannlowski Udo⁵^ORCID,Grotegerd Dominik,Goltermann Janik⁶,Meinert Susanne⁷^ORCID,Kircher Tilo,Stein Frederike,Brosch Katharina^ORCID,Krug Axel⁸^ORCID,Nenadic Igor⁹,Sim Kang,Piras Fabrizio¹⁰^ORCID,Banaj Nerisa¹⁰^ORCID,Sponheim Scott¹¹^ORCID,Demro Caroline¹¹,Ramsay Ian¹²^ORCID,King Margaret,Quidé Yann¹³^ORCID,Green Melissa¹⁴^ORCID,Nguyen Dana,Preda Adrian¹⁵,Calhoun Vince¹⁶^ORCID,Turner Jessica¹⁷^ORCID,Erp Theo van¹⁸,Spalletta Gianfranco

Affiliation:

1. University of Iowa Health Care

2. University of Iowa

3. University of Zurich

4. Psychiatric University Hospital Zurich

5. Institute for Translational Psychiatry, University of Münster

6. University of Muenster

7. University of Münster

8. University of Bonn

9. Philipps University Marburg / Marburg University Hospital

10. IRCCS Santa Lucia Foundation

11. Minneapolis VA Health Care System

12. University of Minnesota

13. The University of New South Wales

14. University of New South Wales

15. UC Irvine

16. Georgia Institute of Technology, Emory University and Georgia State University

17. Georgia State University

18. University of California Irvine

Abstract

Abstract Formal thought disorder (FTD) is a key clinical factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume deficiencies in schizophrenia remain to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles based on a large multi-site cohort through the ENIGMA Schizophrenia Working Group (752 individuals with schizophrenia and 1256 controls), to unravel the neuroanatomy of positive, negative and total FTD in schizophrenia and their cellular bases. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks for positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD was also linked to microglial cell types. These findings relate different dimensions of FTD to distinct brain structural changes and their cellular underpinnings, improve our mechanistic understanding of these key psychotic symptoms.

Publisher

Research Square Platform LLC

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