Affiliation:
1. Wake Forest University
2. University of Mississippi medical Center
3. University of Mississippi Medial Center
4. University of Mississippi
5. 3. Frank Porter Graham Child Development Institute, University of North Carolina
6. Children’s Hospital of Orange County
Abstract
Abstract
Objective
Determine the risk factors of cerebellar injury in infants with surgical necrotizing enterocolitis (NEC).
Methods
Retrospective study compared clinical/pathological information between surgical NEC infants with and those without cerebellar injury.
Results
Infants with cerebellar injury (21/65, 32.3%) had significantly more hemorrhagic and the reparative lesions on the intestinal histopathology, had patent ductus arteriosus (PDA) more often, received red cell transfusion frequently, had blood culture positive sepsis and grew gram positive organisms more often and had cholestasis frequently following NEC than those without cerebellar injury. On multilogistic regression, the positive blood culture sepsis (OR 3.9, CI 1.1–13.7, p = 0.03), PDA (OR 4.5, CI 1.0-19.9, p = 0.04) and severe hemorrhage (grade 3–4)(OR 16.9, CI 2.1-135.5, p = 0.007) were independently associated with higher risk of cerebellar injury.
Conclusion
The cerebellar injury was most likely associated with positive blood culture sepsis following NEC, PDA, and severe hemorrhage lesions (grade 3–4) in infants with surgical NEC.
Publisher
Research Square Platform LLC