Gastroblastoma without GLI1 and EWSR1 gene breaks

Abstract

Abstract Gastroblastoma (GB),a newly discovered gastric tumor with epithelial and diaphthytal differentiation,was first reported in 2009 by Miettinen et al. So far,a total of 17 cases have been reported in domestic and foreign literature,of which 13 cases were reported in the English literature,4 cases were reported in the Chinese literature,6 of 17 cases had confirmed MALAT1-GLI1 fusion gene;1 case found EWSR1-CTBP1 fusion gene. WHO (2019) included the classification of digestive system tumors for the first time. Because gastroblastoma is very rare and has a bidirectional differentiation in morphology,the differential diagnosis of them with other bidirectional tumors of the stomach (such as synovial sarcoma and sarcomatoid carcinoma) and various gastric tumors characterized by relatively mild epithelioid or spindle cells has become very difficult and easy to misdiagnosis. In this paper,a 19-year-old woman,reviewed the relevant literature,summarized the findings,discussed the clinical characteristics,pathological histology,diagnosis,differential diagnosis,treatment and prognosis,so as to improve clinical and pathological awareness of the disease,and reduce misdiagnosis and mistreatment.