Abstract
Background: The ATOH7 genes are established in the retina for optical nerve formation and ganglion cell maturation. Several data and reviews suggested that ATOH7 is known to be vertebrate Math5. So, the Math5 (ATHO7) gene is revealed in the neural retina for the genesis of retina ganglion cells and ocular or optic nerves. The primary neuron in the retina has been generalized in the eyes. The neuron-specific ATOH7 from the atonal gene family plays a fundamental role in neurons during retinal cell proliferation. The evolutionary wonderful eye patterns require atonal gene response at the initial state of retinal neuron growth. Therefore, the growth of the neuron in the retina requires inherited and peripheral elements.
Objective: In this study, the objective is to investigate the Math5 gene mutation in mammalian genomes. Therefore, perform powerful bioinformatics and computational techniques and tools for the current knowledge of ATOH7 gene mutations in two different organisms’ genomes.
Results: Genome-wide observation suggested the total number of bHLH domains in Homo sapiens, Pan Troglodytes, Gorillas, Ailuropoda melanoleuca, and Mus musculus. Further, bioinformatics and comparative analysis results documented the total numbers of ATOH7 genes and their family in all organisms. Also, the conserved domain, motifs, phylogeny, chromosome location, gene network, and gene expression demonstrated that the ATHO7 gene is associated with optical nerve formation and ganglion cell maturation.
Remarks: Therefore, finding data concluded the Math5 gene plays a fundamental role during retinogenesis. So, the ATOH7 or Math5 gene specified ocular nerve formation and ganglion cell maturation.