Effect of Real-Time Audio Ventilation Feedback Device on Survival Rate and Outcomes of Patients with Out-of-Hospital Cardiac Arrest: Prospective randomized controlled study. [Address of organization]

Abstract

Abstract Background The purpose of this study was to conduct the effect of real-time audio ventilation feedback on the survival of out-of-hospital cardiac arrest(OHCA) patients during advanced cardiac life support(ACLS) performed by paramedics.Methods This study was a prospective randomized controlled study in Busan, South Korea from July 2022 to December 2022.The patients of this study were 121 aged 19 years or older who were transferred to the study institution excluding 91 patients who withholding CPR under doctor's direction and 'Do not resuscitation (DNR) state among 212 adult CA patients. OHCA patients were randomly assigned to compare clinical prognosis using a randomized a general manual defibrillator (NVF) group (N = 58) and a manual defibrillator with audio ventilation feedback (AVF) group (N = 63). To verify the primary outcome, the cerebral performance category (CPC), return of spontaneous consciousness(ROSC), 30 hours survival, and survival discharge were compared. And multivariate logistic regression was conducted to analyze the association of us between the audio-feedback manual defibrillator (AVF) and the ROSC of OCHA patients.Results This study analyzed 121 patients among 212 OCHA patients. The ROSC (AVF group: 32{26.4%} vs. NVF group: 21 {17.3%}), 24-hour survival (AVF group: 24 {19.8%} vs. NVF group: 11 {9.0%}), and survival discharge (AVF group: 12 {9.9%} vs. NVF group: 6 {4.9%}) were higher AVF group than NVF group. But, analyzed CPC scores in surviving patients between the two groups, there was no significant difference (AVF group:4.1 ± 1.23 vs. NVF group: 4.7 ± 1.23, p = 1.232). Multivariate logistic regression analysis showed that the use of AVF was associated with a higher ROSC (odds ratio {OR}, 0.46; 95% confidence interval {CI}, 0.23–0.73; P < 0.01) and higher survival at 30 hours (OR, 0.63; 95% CI, 0.41–0.98; p = 0.01).Conclusion The use of the audio ventilation feedback has been associated with a higher ROSC and higher survival at 30 hours after CA.