Association of preptin and glycemic status in individuals with non-alcoholic fatty liver

Abstract

Abstract Context: Preptin is a hormone which is co-secreted with insulin and amylin from beta cells of pancreas. Non-alcoholic fatty liver is a disorder in which there's excessive fat accumulation in the liver cells without evidence of alcohol consumption. Both T2DM and NAFLD is associated with various peptide hormone, but the association of preptin with Non-alcoholic fatty liver and it’s different stages is still not clear. Aim and objective: To determine the level of preptin in T2DM patients with NAFLD and to assess the levels of liver enzymes. To correlate preptin levels with liver enzymes and stages of NAFLD. Settings and Design: Analytical cross sectional study Methods and Material: This is an analytical cross sectional study comprising of 64 T2DM patients divided into two groups based on their glycemic controls with HbA1c more than 8%, ALT ≤ 40 IU/L and ALT ≥ 40 IU/L in SRM Medical College Hospital and Research Centre Diabetology OP and MHC in the age group of 35-80. Statistical analysis used: The data was analysed using statistical package of social service (SPSS 26.0). Results: Plasma preptin levels are increased in patients with T2DM and NAFLD. The NAFLD score and TyG index showed a positive correlation in participants in group 2. In group 2 patients there is a positive correlation between NAFLD score and AST, ALT, ALP, GGT, while TyG index shows a positive correction with LDL and VLDL in both groups. Conclusions: Preptin may have a role in the pathophysiology of NAFLD and may be a valuable marker in predicting fibrosis development along with NAFLD score.