Effect of pretreatment with a small dose of esketamine on sufentanil-induced cough during anesthesia induction: A randomized controlled trial

Abstract

Abstract Background Sufentanil-induced cough is common during the induction of anesthesia. The objective of this study was to determine whether pretreatment with a small dose of esketamine is effective in treating sufentanil-induced cough. Methods 220 patients were screened, and 200 patients who had scheduled elective surgery and were between 18 and 70 years old were randomly divided into two groups. Before sufentanil was administered, group K was injected with 0.15 mg/kg esketamine at 5 s, and group C was administered with the same volume. Within 1 minute after sufentanil(0.4ug/kg) injection during induction, cough incidence and severity were evaluated. After sufentanil was injected, we recorded its hemodynamic changes and side effects. Results In the group K and group C, there was an incidence of cough of 5 and 34%, respectively. The K group had a significantly lower incidence and severity of cough compared to the C group immediately after sufentanil injection (P < 0.05). MAP and HR did not differ significantly between the two groups during three different times of general anesthesia induction (P > 0.05). Conclusion In our study, we found that sufentanil-induced cough was significantly reduced by pretreatment with 0.15mg/kg esketamine, but with no significant changes in the hemodynamic status. Trial registration: Chinese Clinical Trial Registry (ChiCTR2200063821, registered date: 17/09/2022), http://www.chictr.org.cn