Examination of the presence of periodontitis and gingivitis in rats with induced diabetes mellitus-Reference-Cited by-同舟云学术

Examination of the presence of periodontitis and gingivitis in rats with induced diabetes mellitus

Published:2023 Issue:3 Volume:70 Page:131-137
ISSN:0039-1743
Container-title:Serbian Dental Journal
language:en
Short-container-title:SERBIAN DENT J

Author:

Kuzmanovic-Radman Irena¹,Arbutina Adriana²^ORCID,Josipovic Renata¹,Marin Sasa³^ORCID,Umicevic-Davidovic Mirjana²,Arbutina Radmila¹,Trtic Natasa⁴,Vrhovac Bojan⁵,Djeri Aleksandra¹

Affiliation:

1. University of Banja Luka, Faculty of Medicine, Department of Dental Diseases, Banja Luka, Bosnia and Herzegovina

2. University of Banja Luka, Faculty of Medicine, Department of Orthodontics, Banja Luka, Bosnia and Herzegovina

3. University of Banja Luka, Faculty of Medicine, Department of Oral Surgery, Banja Luka, Bosnia and Herzegovina

4. University of Banja Luka, Faculty of Medicine, Department of Periodontology and Oral Diseases, Bosnia and Herzegovina

5. ZU “Dr Đurić”, Banja Luka, Bosnia and Herzegovina

Abstract

Introduction. Diabetes mellitus (DM) is a state of chronic hyperglycemia that is a predisposing factor to caries, gingivitis, inflammation of periodontium, oral candidiasis, xerostomia and many other diseases of the oral cavity. Inflammation of the supporting tissue of the tooth is a chronic disease that destroys the supporting structure of the tooth, i.e. periodontal ligament and alveolar bone. The aim of this study was to examine using histological analysis the presence of periodontitis and gingivitis in rats with experimentally induced DM that were sacrificed after 14 and 30 days. Material and methods. The research was conducted on 42 Wistar rats. DM in experimental animals was induced by the use of Alloxan intraperitoneally. The first group (Exp_14) consisted of 16 rats in which DM was induced and sacrificed after 14 days, the second group (Exp_30) consisted of 16 rats in which DM was induced and they were sacrificed after 30 days, while the control consisted of 10 healthy rats. Results. Periodontitis and gingivitis in the first group of rats (Exp_14) were determined in 54.5% of cases, while in the second group (Exp_30) in 88% of cases. In the control group no case of periodontitis and gingivitis was recorded. A highly statistically significant difference was found between the examined groups (Chi-square = 14.685; p < 0.001). Conclusion. In the group of rats with experimentally induced DM that were sacrificed after 30 days, a significantly higher incidence of periodontitis and gingivitis was found compared to the group of rats that were sacrificed after 14 days.

Publisher

National Library of Serbia

Subject

General Medicine,General Chemistry

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