Akut ve Kronik Miyeloid Lösemili Hastalarda Prognostik miRNA İmzasının Biyoinformatik Analiz ile Karşılaştırılması

Abstract

Aim: In this study, differentially expressed miRNA profiles were determined using high-throughput expression data from samples of AML and CML patients to identify miRNAs involved in the therapeutic response. Material and Methods: miRNA microarray datasets GSE142699 and GSE90773 were downloaded via the GEO database and analysis was performed with the online analysis tool GEO2R. Data no. GSE142699 was made with 24 control and 24 newly diagnosed AML patients, data no. GSE90773 was made with 8 control and 10 newly diagnosed CML patients. After the analysis, they were grouped according to fold change (FC) values and p