High expression of centromere protein A and its molecular mechanism and clinical significance in prostate cancer: A study based on data mining and immunohistochemistry

Author:

Jiang Fang‐Cheng1,Zhai Gao‐Qiang2,Liu Jia‐Lin2,Wang Rui‐Gong2,Yang Yuan‐Ping1,Murugesan Harivignesh1,Yu Xiao‐Xiang3,Du Xiu‐Fang1,He Juan1,Feng Zhen‐Bo1,Pan Shang Ling4,Chen Gang1,Li Sheng‐Hua2ORCID,Huang Zhi‐Guang1ORCID

Affiliation:

1. Department of Pathology The First Affiliated Hospital of Guangxi Medical University Nanning China

2. Department of Urology The First Affiliated Hospital of Guangxi Medical University Nanning China

3. Department of Urology The 923rd Hospital of Chinese People's Liberation Army Joint Logistics Support Force Nanning China

4. Department of Pathophysiology School of Pre‐clinical Medicine Guangxi Medical University Nanning Guangxi China

Abstract

AbstractThe progression of prostate cancer (PCa) leads to poor prognosis. However, the molecular mechanism of PCa is still not completely clear. This study aimed to elucidate the important role of centromere protein A (CENPA) in PCa. Large numbers of bulk RNA sequencing (RNA‐seq) data and in‐house immunohistochemistry data were used in analysing the expression level of CENPA in PCa and metastatic PCa (MPCa). Single‐cell RNA‐seq data was used to explore the expression status of CENPA in different prostate subpopulations. Enrichment analysis was employed to detect the function of CENPA in PCa. Clinicopathological parameters analysis was utilised in analysing the clinical value of CENPA. The results showed that CENPA was upregulated in PCa (standardised mean difference [SMD] = 0.83, p = 0.001) and MPCa (SMD = 0.61, p = 0.029). CENPA was overexpressed in prostate cancer stem cells (CSCs) with androgen receptor (AR) negative compared to epithelial cells with AR positive. CENPA may influence the development of PCa through affecting cell cycle. Patients with nodal metastasis had higher expression level of CENPA. And patients with high CENPA expression had poor disease‐free survival. Taken together, Overexpression of CENPA may influence the development of PCa by regulating cell cycle and promoting metastasis.

Publisher

Institution of Engineering and Technology (IET)

Subject

Cell Biology,Genetics,Molecular Biology,Modeling and Simulation,Biotechnology

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