The role of CKIP-1 in osteoporosis development and treatment-Reference-Cited by-全球学者库

The role of CKIP-1 in osteoporosis development and treatment

Published:2018-02 Issue:2 Volume:7 Page:173-178
ISSN:2046-3758
Container-title:Bone & Joint Research
language:en
Short-container-title:Bone & Joint Research

Author:

Peng X.¹,Wu X.¹,Zhang J.²,Zhang G.³,Li G.²,Pan X.¹

Affiliation:

1. Department of Orthopaedics and Traumatology, People’s Hospital of Bao’an District, Affiliated to Southern Medical University, and Affiliated to Guangdong Medical University, Longjing 2nd Rd, Bao’an District, Shenzhen, China

2. Department of Orthopaedics and Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China

3. Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Baptist University Road, Kowloon Tong, Hong Kong, China

Abstract

Osteoporosis is a systemic skeletal disorder characterized by reduced bone mass and deterioration of bone microarchitecture, which results in increased bone fragility and fracture risk. Casein kinase 2-interacting protein-1 (CKIP-1) is a protein that plays an important role in regulation of bone formation. The effect of CKIP-1 on bone formation is mainly mediated through negative regulation of the bone morphogenetic protein pathway. In addition, CKIP-1 has an important role in the progression of osteoporosis. This review provides a summary of the recent studies on the role of CKIP-1 in osteoporosis development and treatment. Cite this article: X. Peng, X. Wu, J. Zhang, G. Zhang, G. Li, X. Pan. The role of CKIP-1 in osteoporosis development and treatment. Bone Joint Res 2018;7:173–178. DOI: 10.1302/2046-3758.72.BJR-2017-0172.R1.

Publisher

British Editorial Society of Bone & Joint Surgery

Subject

Orthopedics and Sports Medicine,Surgery

Link

https://online.boneandjoint.org.uk/doi/pdf/10.1302/2046-3758.72.BJR-2017-0172.R1

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