Affiliation:
1. Institute of Biology, Federal Research Center Komi Science Center of the Ural Branch of the Russian Academy of Sciences
2. Institute of Molecular Biology named after V.A. Engelhardt of the Russian Academy of Sciences
Abstract
The search for drugs that slow down the rate of aging and stimulate radioresistance is an urgent task of biology, ecology, and medicine. In this work we have studied the effects of trichostatin A and berberine on the lifespan, resistance to the paraquat prooxidant and acute gamma irradiation of the Drosophila melanogaster fruit fly. Trichostatin A demonstrated a better geroprotective effect, increasing the Drosophila lifespan by 3-9 %. However, an increase in radioresistance was observed only after the application of berberine in males. Their median survival after gamma irradiation increased by 25 %. Trichostatin A, on the contrary, increased the sensitivity of flies to gamma irradiation genotoxic effects, reducing the survival by 7-17 %.
Subject
General Earth and Planetary Sciences,General Energy
Reference69 articles.
1. Da Costa, J. P. A synopsis on aging-theories, mechanisms and future prospects / J. P. da Costa, R. Vitorino, G. M. Silva [et al.] // Ageing Res Rev. – 2016. – Vol. 29. – P. 90-112., Da Costa, J. P. A synopsis on aging-theories, mechanisms and future prospects / J. P. da Costa, R. Vitorino, G. M. Silva [et al.] // Ageing Res Rev. – 2016. – Vol. 29. – P. 90-112.
2. Moskalev, A. A. Genetics and epigenetics of aging and longevity / A. A. Moskalev, A. M. Aliper, Z. Smit-McBride [et al.] // Cell Cycle. – 2014. – Vol. 13. – № 7. – P. 1063-77., Moskalev, A. A. Genetics and epigenetics of aging and longevity / A. A. Moskalev, A. M. Aliper, Z. Smit-McBride [et al.] // Cell Cycle. – 2014. – Vol. 13. – № 7. – P. 1063-77.
3. Dues, D. J. Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways / D. J. Dues, E. K. Andrews, C. E. Schaar [et al.] // Aging (Albany NY). – 2016. – Vol. 8. – № 4. – P. 777-95., Dues, D. J. Aging causes decreased resistance to multiple stresses and a failure to activate specific stress response pathways / D. J. Dues, E. K. Andrews, C. E. Schaar [et al.] // Aging (Albany NY). – 2016. – Vol. 8. – № 4. – P. 777-95.
4. Marion, J. The effects of radiation on the longevity of female Drosophila subobscura / J. Marion, Lamb // Journal of Insect Physiology. –1964. –Vol. 10. – № 3. – P. 487-497., Marion, J. The effects of radiation on the longevity of female Drosophila subobscura / J. Marion, Lamb // Journal of Insect Physiology. –1964. –Vol. 10. – № 3. – P. 487-497.
5. Gaman, L. Can ageing be slowed: Hormetic and redox perspectives / L. Gaman, I. Stoian, V. Atanasiu // J Med Life. –2011. – Vol. 4. – № 4. – P. 346-51., Gaman, L. Can ageing be slowed: Hormetic and redox perspectives / L. Gaman, I. Stoian, V. Atanasiu // J Med Life. –2011. – Vol. 4. – № 4. – P. 346-51.