Exploring the neuroprotective effects of chokeberry (×Sorbaronia mitschurinii) extract on Drosophila melanogaster model of Alzheimer’s disease-Reference-Cited by-同舟云学术

Exploring the neuroprotective effects of chokeberry (×Sorbaronia mitschurinii) extract on Drosophila melanogaster model of Alzheimer’s disease

Published:2023-10-25 Issue:6 Volume:0 Page:86-93
ISSN:1994-5655
Container-title:Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences
language:en
Short-container-title:

Author:

Zemskaya N.¹,Pakshina N.¹,Platonova E.¹,Shaposhnikov M.¹,Moskalev A.¹²

Affiliation:

1. Institute of Biology, Federal Research Center Komi Science Center of the Ural Branch of the Russian Academy of Sciences

2. Institute of Molecular Biology named after V.A. Engelhardt of the Russian Academy of Sciences

Abstract

Aging is accompanied by a widespread deterioration in the state of the body (physiological and psychological) with the concomitant manifestation of neurodegenerative diseases (dementia, Alzheimer’s disease, Parkinson’s disease). Biologically active substances contained in the fruits of chokeberry have previously shown a neuroprotective potential in relation to model organisms in vivo, so we put forward a hypothesis about the possible neurodenegeroprotective potential of the ethanol extract of chokeberry (×Sorbaronia mitschurinii) on Drosophila melanogaster with overexpression of the precursor of human beta-amyloid UAS-Aβ42. Its accumulation in human brain cells triggers the development of Alzheimer’s disease. In this work, we have studied the effect of chokeberry extract at a concentration of 10 mg/ml on the lifespan of Drosophila model of Alzheimer’s disease. The extract increases the median and maximum lifespan of females by 11 %, as well as the median lifespan of males by 2 % but reduces their maximum lifespan by 3 %. These results indicate the neuroprotective effect of chokeberry extract.

Publisher

Komi SC UB RAS

Subject

General Earth and Planetary Sciences,General Energy

Reference52 articles.

1. Tuso, P. J. Nutritional update for physicians: plant-based diets / P. J. Tuso, M. H. Ismail, B. P. Ha, C. Bartolotto // Perm J. – 2013. – Vol. 17, № 2. – P. 61-66., Tuso, P. J. Nutritional update for physicians: plant-based diets / P. J. Tuso, M. H. Ismail, B. P. Ha, C. Bartolotto // Perm J. – 2013. – Vol. 17, № 2. – P. 61-66.

2. Leitzmann, C. Characteristics and health benefits of phytochemicals / C. Leitzmann // Forsch Komplementmed. – 2016. – Vol. 23, № 2. – P. 69-74., Leitzmann, C. Characteristics and health benefits of phytochemicals / C. Leitzmann // Forsch Komplementmed. – 2016. – Vol. 23, № 2. – P. 69-74.

3. Del Rio, D. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases / D. Del Rio, A. Rodriguez-Mateos, J. P. Spencer, M. Tognolini, G. Borges [et al.] // Antioxid Redox Signal. – 2013. – Vol. 18, № 14. – P. 1818-1892., Del Rio, D. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases / D. Del Rio, A. Rodriguez-Mateos, J. P. Spencer, M. Tognolini, G. Borges [et al.] // Antioxid Redox Signal. – 2013. – Vol. 18, № 14. – P. 1818-1892.

4. Mekinić, I.G. Antioxidant and antimicrobial potential of phenolic metabolites from traditionally used Mediterranean herbs and spices / I. G. Mekinić, D. Skroza, I. Ljubenkov, V. Katalinić, V. Šimat // Foods. – 2019. – Vol. 8, № 11., Mekinić, I.G. Antioxidant and antimicrobial potential of phenolic metabolites from traditionally used Mediterranean herbs and spices / I. G. Mekinić, D. Skroza, I. Ljubenkov, V. Katalinić, V. Šimat // Foods. – 2019. – Vol. 8, № 11.

5. Platonova, E. Y. Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria / E.Y. Platonova, M.V. Shaposhnikov, H.-Y. Lee, J.-H. Lee, K.-J. Min [et al.]// Trends in Food Science & Technology. – 2021. – Vol. 114 – P. 570-584., Platonova, E. Y. Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria / E.Y. Platonova, M.V. Shaposhnikov, H.-Y. Lee, J.-H. Lee, K.-J. Min [et al.]// Trends in Food Science & Technology. – 2021. – Vol. 114 – P. 570-584.