Abstract
The aim. To analyze the microbiological spectrum of pathogens causing surgical site infections and their antibiotic resistance in surgical patients injured during the military conflict between Ukraine and Russia.
Materials and methods. This study was based on 137 bacteriological examinations of biological samples from patients treated in the surgical department of the Kyiv City Oleksandrivska Clinical Hospital in 2022. The samples included 81cultures isolated from postoperative wounds and 56 cultures from the abdominal cavity. Susceptibility to antibacter drugs was determined according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards. Statistical analysis was performed using IBM SPSS Statistics.
Results. Among the 137 analyzed samples, the most common pathogens were Klebsiella pneumoniae (22.6%), Enterococcus faecalis (13.1%), Staphylococcus epidermidis (13.1%), Pseudomonas aeruginosa (11.6%), and Escherichia coli (10.2%). In the abdominal cavity samples (n = 56), E. coli was predominant (17.9%), followed by K. pneumoniae (16.1%), E. faecalis (16.1%), S. epidermidis (10.7%), Candida (8.9%), and P. aeruginosa (7.1%). In postoperative wound samples (n = 81), K. pneumoniae was found in 27.2%, P. aeruginosa in 14.8%, S. epidermidis in 14.8%, S. aureus in 12.3%, and E. faecalis in 11.1%.
K. pneumoniae showed high resistance to amikacin (86.6%), meropenem (74.2%), piperacillin-tazobactam (82.8%), and ceftriaxone (86.2%). E. faecalis exhibited resistance to imipenem (58.8%), levofloxacin (47.1%), and vancomycin (12.5%). S. epidermidis had resistance to gentamicin (13.3%), meropenem (50%), and oxacillin (35.7%). P. aeruginosa demonstrated resistance to ciprofloxacin (45.6%), meropenem (67.4%), ceftazidime (52.3%), and piperacillin-tazobactam (48.7%).
Conclusion. The primary pathogens causing surgical site infections in military surgical patients are K. pneumoniae, E. faecalis, S. epidermidis, P. aeruginosa, and E. coli. The pathogen spectrum varies between abdominal cavity infections and postoperative wound infections. There is a clear trend towards increased detection of antibiotic-resistant pathogens, particularly among military personnel. Colonization with resistant microorganisms increases during medical evacuation through different levels of the evacuation chain.
Publisher
Professional Edition Eastern Europe
Reference29 articles.
1. WHO [Internet]. Geneva: World Health Organization; c2019 [cited 2024 Mar 12]. Meeting report: WHOtechnical consultation: nutrition-related health products and the World Health Organization model list of essentialmedicines – practical considerations and feasibility:Geneva, Switzerland, 20–21 September 2018. Available from: https://iris.who.int/handle/10665/311677
2. Blyth DM, Yun HC, Tribble DR, Murray CK. Lessons of war: Combat-related injury infections during the Vietnam Warand Operation Iraqi and Enduring Freedom. J Trauma Acute Care Surg. 2015;79(4 Suppl 2):S227-S235. https://doi.org/10.1097/TA.0000000000000768
3. Kondratiuk V, Jones BT, Kovalchuk V, Kovalenko I, Ganiuk V, Kondratiuk O, et al. Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020. J Hosp Infect. 2021;112:69-76. https://doi.org/10.1016/j.jhin.2021.03.020
4. European Centre for Disease Prevention and Control. Stockholm: ECDC; c2022 [cited 2024 Apr 6]. Operational public health considerations for the prevention and control of infectious diseases in the context of Russia’s aggression towards Ukraine. Available from: https://www.ecdc.europa.eu/en/publications-data/operational-public-health-considerations-prevention-and-control-infectious
5. Schultze T, Hogardt M, Velázquez ES, Hack D, Besier S, Wichelhaus TA, et al. Molecular surveillance of multidrug-resistant Gram-negative bacteria in Ukrainian patients, Germany, March to June 2022. Euro Surveill. 2023;28(1):2200850. https://doi.org/10.2807/1560-7917.ES.2023.28.1.2200850
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