Abstract
The tools of genome editing were described more than a decade ago as promising ways to accelerate crop improvement in addition to applications for human and animal health. Now, a decade later, we are seeing applications of genome editing across a range of different crops and trait combinations that will bring benefits to producers and consumers. Countries around the world are actively engaged in updating regulatory frameworks to govern this new technology adequately. In this paper, we describe recent advances in genome editing tools, review select applications underway, consider the benefits of the technology, and offer a perspective on significant challenges to the success of the use of genome editing. Given an enabling policy environment, genome editing will be an important tool in creating a competitive bioeconomy while addressing major challenges to agriculture and consumers. We offer five recommendations to ensure genome editing in agriculture benefits society
Publisher
Council for Agricultural Science and Technology
Reference94 articles.
1. Abdallah NA, Prakash CS, and McHughen AG. 2015. Genome Editing for Crop Improvement: Challenges and Opportunities. GM Crops & Food 6(4):183-205. https://doi.org/10.1080/21645698.2015.1129937.
2. Alliance for Science. 2023. The €3 Trillion Cost of Saying No: How the Eu Risks Falling Behind in The Bioeconomy Revolution A New Report by The Breakthrough Institute and The Alliance For Science. https://allianceforscience.org/wp-content/uploads/2023/10/Foregone-benefits-of-gene-editing-in-the-EU_FINAL.pdf.
3. Alvarez D, Cerda-Bennasser P, Stowe E, Ramirez Torres F, Capell T, Dhingra A, Christou P. 2021. Fruit Crops in the Era of Genome Editing: Closing the Regulatory Gap. Plant Cell Reports 40:915-930, https://doi.org/10.1007/s00299-021-02664-x.
4. Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby, GA, Reguram, A, et al. 2019. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature 576,49-157, https://doi.org/10.1038/s41586-019-1711-4.
5. Bate NJ, Dardick CD, de Maagd, RA, Williams, RW. 2021. Opportunities and challenges applying gene editing to specialty crops. In Vitro Cell Dev Biol-Plant 57:709-719, https://doi.org/10.1007/s11627-021-10208-x.