1. ) followed by two rounds of analog modeling of make-ondemand compound libraries led to the discovery of potent MRGPRX2 inverse agonists namely C9-6 and C9, for which K i values of 58 nM and 43 nM vs. 3 �M of (R)-ZINC-3573 were determined in calcium assays in HEK293 cells expressing MRGPRX2;Furuno Ogasawara;Based on the above scaffold (X2-124, Table 10), searching of the ZINC database,2019
2. Morphine is an exogenous ligand for MrgX2, a G protein-coupled receptor for cortistatin;N Akuzawa;Journal Cell and Animal Biology,2007
3. The CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors;S P Alexander;British Journal of Pharmacology,2021
4. Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions;H Ali;Advances in Immunology,2017