Correcting the Aberrant Progranulin-Deficient Lysosomal Proteome via HDAC Inhibition

Author:

Werthmann Gordon C.,Tesla Rachel J.,Wong Connie H.,Haggarty Stephen J.,Herz Joachim

Publisher

Elsevier BV

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference56 articles.

1. SAHA treatment improved 15 proteins < 33% (C), improved 20 proteins;Grn +/-endo-lysosomes (n=3; ANOVA and post-hoc Tukey HSD test p < 0.05)

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3. Lysosomal metabolomics reveals V-ATPase-and mTOR-dependent regulation of amino acid efflux from lysosomes;M Abu-Remaileh;Science,2017

4. Accelerated Lipofuscinosis and Ubiquitination in Granulin Knockout Mice Suggest a Role for;Z Ahmed;Progranulin in Successful Aging,2010

5. Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases;R A Anderson;J Biol Chem,1991

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