Affiliation:
1. Department of Oncology, People's Hospital of Tongzhou District, Nantong City, Jiangsu Province
2. Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China
Abstract
Background Partial splenic artery embolization is an effective treatment for hypersplenism but often lacks long-term benefits. Purpose To evaluate the long-term effects of coil embolization of the splenic artery in patients with liver cirrhosis and hypersplenism. Material and Methods Forty-nine patients with liver cirrhosis and hypersplenism underwent coil embolization of the main splenic artery. The coils were deployed in the mid- or distal segment of the splenic artery to allow collateral blood flow to the spleen. The following data were collected from 2 weeks to 4 years after the embolization: technical success, length of hospital stay, white blood cell count, platelet count, splenic volume, and complication. Results The technical success rate of splenic artery coil embolization was 100%. The post embolization syndrome rate was 75% (36/49) with no incidence of major complications. The mean length of hospital stay was 9 days. After embolization, the patient's white blood and platelet counts increased significantly, peaked at 2 weeks, and gradually decreased during the 4-year follow-up period, but remained at significantly higher levels than pre-embolization levels. Follow-up CT scans demonstrated a gradual increase in the volume of the enhanced portions of the spleens with a decrease in the volume of unenhanced portion. No significant changes occurred in the red blood cell count and liver function after the embolization. Conclusion Embolization of the mid-and distal main splenic artery with coils is a safe and effective treatment of hypersplenism in cirrhosis with long-term hematologic benefits.
Subject
Radiology, Nuclear Medicine and imaging,General Medicine,Radiological and Ultrasound Technology
Cited by
24 articles.
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