Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats-Reference-Cited by-同舟云学术

Pharmaco-EEG Analysis of the Effect of Acetylcholin and Insulin in Nanoparticles on the Hippocampus of Cats

Published:2023-10-05 Issue:3 Volume:19 Page:58-65
ISSN:2713-0428
Container-title:Journal Biomed
language:
Short-container-title:BIOMEDICINE

Author:

Fokin Yu. V.¹,Kharitonov S. Yu.¹,Taboyakova L. A.¹,Karkischenko N. N.¹

Affiliation:

1. Scientific Center of Biomedical Technologies of the Federal Medical and Biological Agency of Russia

Abstract

The central mechanisms of acetylcholine and insulin in nanoparticles via transpalatinal administration to cats were studied using a neuroimaging algorithm, including a software-supported pharmaco-EEG analysis of graphic functions of normalized electrograms. The studied substances were found to exhibit a predominantly depressing action, which begins in the first hours after administration. Liposomal forms of acetylcholine and insulin penetrate the blood-brain barrier and modulate the intracentral relations of the brain, reflected in high-frequency rhythms (mainly γ-rhythms) of the hippocampal region of the brain and associated with the activity of intercalary neurons and pyramidal cells. The substances under study appear to be promising for the prevention and treatment of neuropathies caused, e.g., by geriatric dysfunctions of the cholinergic and insulin signaling systems, as well as for improving memory consolidation and cognitive functions.

Publisher

Scientific Center for Biomedical Technologies of the Federal Medical-Biological Agency

Subject

General Medicine

Reference10 articles.

1. Karkishchenko V.N., Fokin Yu.V., Lyublinskii S.L., Pomytkin I.A., Alimkina O.V., Taboyakova L.A., Kaptsov A.V., Borisova M.M., Karkishchenko N.N. Tsentral'nye mekhanizmy liposomirovannykh form atsetilkholina i insulina posredstvom analiza kognitivnykh, psikhoemotsional'nykh i povedencheskikh parametrov krys. Biomeditsina. 2022;18(1):32-55. [Karkischenko V.N., Fokin Yu.V., Lyublinskiy S.L., Pomytkin I.A., Alimkina O.V., Taboyakova L.A., Kaptsov A.V., Borisova M.M., Karkischenko N.N. Tsentral'nye mekhanizmy liposomirovannykh form atsetilkholina i insulina posredstvom analiza kognitivnykh, psikhoemotsional'nykh i povedencheskikh parametrov krys [Central mechanisms of liposomated forms of acetylcholin and insulin by analysis of cognitive, psycho-emotional and behavioral parameters of rats]. Biomeditsina [Journal Biomed]. 2022;18(1):32–55. (In Russian)]. DOI: 10.33647/2074-5982-18-1-32-55.

2. Karkishchenko N.N., Fokin Yu.V., Karkishchenko V.N., Taboyakova L.A., Mokrousov M.I., Alimkina O.V. Konvergentnaya validatsiya intratsentral'nykh otnoshenii golovnogo mozga zhivotnykh. Biomeditsina. 2017;3:16–39. [Karkischenko N.N., Fokin Yu.V., Karkischenko V.N., Taboyakova L.A., Mokrousov M.I., Alimkina O.V. Konvergentnaya validatsiya intratsentral'nykh otnosheniy golovnogo mozga zhivotnykh [Convergent validation of intracentral relationships of the brain of animals]. Biomeditsina [Journal Biomed]. 2017;3:16–39. (In Russian)].

3. Karkishchenko N.N., Fokin Yu.V., Karkishchenko V.N., Taboyakova L.A., Kharitonov S.Yu., Alimkina O.V. Novye podkhody k otsenke intratsentral'nykh otnoshenii po pokazatelyam operantnogo povedeniya i elektrogramm mozga koshek. Biomeditsina. 2018;4:4–17. [Karkischenko N.N., Fokin Yu.V., Karkischenko V.N., Taboyakova L.A., Kharitonov S.Yu., Alimkina O.V. Novye podkhody k otsenke intratsentral'nykh otnosheniy po pokazatelyam operantnogo povedeniya i elektrogramm mozga koshek [New approaches to the assessment of intracentral relations in terms of operant behavior and electrograms of the cats brain]. Biomeditsina [Journal Biomed]. 2018;4:4–17. (In Russian)].

4. Rukovodstvo po laboratornym zhivotnym i al'ternativnym modelyam v biomeditsinskikh issledovaniyakh. Pod red. N.N. Karkishchenko i dr. M.: Profil'-2S, 2010:358. [Rukovodstvo po laboratornym zhivotnym i al'ternativnym modelyam v biomeditsinskikh issledovaniyakh [Manual on laboratory animals and alternative models in biomedical research]. Ed. by N.N. Karkischenko, et al. Moscow: Profil'-2S Publ., 2010:358. (In Russian)].

5. Brass B.J., Nonner D., Barrett J.N. Differential effects of insulin on choline acetyltransferase and glutamic acid decarboxylase activities in neuron-rich striatal cultures. J. Neurochem. 1992;59(2):415–424. DOI: 10.1111/j.1471-4159.1992.tb09387.x.