Beyond energy and growth: the role of metabolism in developmental signaling, cell behavior and diapause

Author:

Tippetts Trevor S.1,Sieber Matthew H.2,Solmonson Ashley3ORCID

Affiliation:

1. Children's Medical Center Research Institute, University of Texas Southwestern Medical Center 1 , Dallas, TX 75390 , USA

2. University of Texas Southwestern Medical Center 2 Department of Physiology , , Dallas, TX 75390 , USA

3. Laboratory of Developmental Metabolism and Placental Biology, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 3 , Dallas, TX 75390 , USA

Abstract

ABSTRACT Metabolism is crucial for development through supporting cell growth, energy production, establishing cell identity, developmental signaling and pattern formation. In many model systems, development occurs alongside metabolic transitions as cells differentiate and specialize in metabolism that supports new functions. Some cells exhibit metabolic flexibility to circumvent mutations or aberrant signaling, whereas other cell types require specific nutrients for developmental progress. Metabolic gradients and protein modifications enable pattern formation and cell communication. On an organism level, inadequate nutrients or stress can limit germ cell maturation, implantation and maturity through diapause, which slows metabolic activities until embryonic activation under improved environmental conditions.

Funder

National Institute on Aging

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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