The dynamics of tubulogenesis in development and disease

Author:

Romero Adrian1,Walker Brandy L.12,Krneta-Stankic Vanja13,Gerner-Mauro Kamryn34,Youmans Lydia1,Miller Rachel K.1256ORCID

Affiliation:

1. Pediatric Research Center, UTHealth McGovern Medical School 1 Department of Pediatrics , , Houston, TX 77030 ,

2. The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Program in Genetics and Epigenetics 2 , Houston, TX 77030 ,

3. The University of Texas MD Anderson Cancer Center 3 Department of Pulmonary Medicine, Division of Internal Medicine , , Houston, TX 77030 ,

4. Baylor College of Medicine 4 , Program in Development, Disease Models & Therapeutics, Houston, TX 77030 ,

5. University of Texas MD Anderson Cancer Center 5 Department of Genetics , , Houston, TX 77030 ,

6. The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Program in Molecular and Translational Biology 6 , Houston, TX 77030 ,

Abstract

ABSTRACT Tubes are crucial for the function of many organs in animals given their fundamental roles in transporting and exchanging substances to maintain homeostasis within an organism. Therefore, the development and maintenance of these tube-like structures within organs is a vital process. Tubes can form in diverse ways, and advances in our understanding of the molecular and cellular mechanisms underpinning these different modes of tubulogenesis have significant impacts in many biological contexts, including development and disease. This Review discusses recent progress in understanding developmental mechanisms underlying tube formation.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston

National Institute of General Medical Sciences

University of Texas MD Anderson Cancer Center

University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences

Publisher

The Company of Biologists

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