1. Neurological Disorders Group, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdiSSC) 1 , Madrid 28040 , Spain
2. University of Oxford 2 Department of Physiology, Anatomy and Genetics , , Oxford OX1 3PT , UK
3. MRC Harwell Institute 3 Mammalian Genetics Unit , , Didcot, Oxfordshire OX11 ORD , UK
4. Wellcome Centre for Integrative Neuroimaging, University of Oxford 4 , Oxford OX3 9D , UK
5. Universidad Complutense de Madrid 5 Department of Medicine , , Madrid 28040 , Spain
6. Mouse Imaging Centre, The Hospital for Sick Children 6 , Toronto, ON M57 3H7 , Canada
7. Mary Lyon Centre at MRC Harwell 7 , Didcot, Oxfordshire OX11 ORD , UK
8. 8 Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK
9. UCL Institute of Prion Diseases 9 MRC Prion Unit at UCL , , University College London, London W1W 7FF , UK