1. Center for Genomic Medicine, Massachusetts General Hospital 1 , Boston, MA 02114 , USA
2. Harvard Medical School 2 Program in Biological and Biomedical Sciences, Division of Medical Science , , Boston, MA 02115 , USA
3. Harvard Medical School 3 Department of Medicine , , Boston, MA 02115 , USA
4. Broad Institute of Harvard and MIT 4 , Cambridge, MA 02142 , USA