MAP kinases and cell migration-Reference-Cited by-同舟云学术

MAP kinases and cell migration

Published:2004-09-15 Issue:20 Volume:117 Page:4619-4628
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Huang Cai¹,Jacobson Ken¹²³,Schaller Michael D.¹²³

Affiliation:

1. Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7090, USA

2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7090, USA

3. Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599-7090, USA

Abstract

Recent studies have demonstrated that mitogen-activated protein kinases (MAPKs), including Jun N-terminus kinase (JNK), p38 and Erk, play crucial roles in cell migration. JNK, for example, regulates cell migration by phosphorylating paxillin, DCX, Jun and microtubule-associated proteins. Studies of p38 show that this MAPK modulates migration by phosphorylating MAPK-activated protein kinase 2/3 (MAPKAP 2/3), which appears to be important for directionality of migration. Erk governs cell movement by phosphorylating myosin light chain kinase (MLCK), calpain or FAK. Thus, the different kinases in the MAPK family all seem able to regulate cell migration but by distinct mechanisms.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/117/20/4619/1531355/4619.pdf

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