Affiliation:
1. Center for Human Disease Modeling, Department of Cell Biology, Duke University, Durham NC 27710, USA.
Abstract
Through the combined study of model organisms, cell biology, cell signaling and medical genetics we have significantly increased our understanding of the structure and functions of the vertebrate cilium. This ancient organelle has now emerged as a crucial component of certain signaling and sensory perception pathways in both developmental and homeostatic contexts. Here, we provide a snapshot of the structure, function and distribution of the vertebrate cilium and of the pathologies that are associated with its dysfunction.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
141 articles.
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