New insights into Fat cadherins
Author:
Tanoue Takuji1, Takeichi Masatoshi1
Affiliation:
1. RIKEN Center for Developmental Biology, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan
Abstract
Cell-cell adhesion is fundamental to multicellular architecture. Several classes of adhesion molecule are used to achieve this, and cadherins represent a major family of such molecules. The cadherin family has multiple subfamilies. Members of the Fat cadherin subfamily, which is conserved across species, have an extraordinarily large extracellular region, comprising 34 repeated domains, making them the largest cadherin molecules. Classic Fat, identified in Drosophila, is known to regulate cell proliferation and planar cell polarity. Recent studies of one of its mammalian homologs, Fat1, have revealed novel functions of this molecule. Fat1 binds to Ena/VASP proteins and regulates actin dynamics at both cell-cell contacts and leading edges. These observations suggest that Fat1 is an important regulator of actin dynamics and controls cell-cell interactions through this activity.
Publisher
The Company of Biologists
Reference61 articles.
1. Adler, P. N., Charlton, J. and Liu, J. (1998). Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling. Development125, 959-968. 2. Ashery-Padan, R., Alvarez-Bolado, G., Klamt, B., Gessler, M. and Gruss,
P. (1999). Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain. Mech. Dev.80, 213-217. 3. Bear, J. E., Svitkina, T. M., Krause, M., Schafer, D. A., Loureiro, J. J.,
Strasser, G. A., Maly, I. V., Chaga, O. Y., Cooper, J. A., Borisy, G. G. et al. (2002). Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell109, 509-521. 4. Bolz, H., von Brederlow, B., Ramirez, A., Bryda, E. C., Kutsche, K.,
Nothwang, H. G., Seeliger, M., del C-Salcedo Cabrera, M., Vila, M. C., Molina, O. P. et al. (2001). Mutation of CDH23, encoding a new member of the cadherin gene family, causes Usher syndrome type 1D. Nat. Genet.27, 108-112. 5. Bork, J. M., Peters, L. M., Riazuddin, S., Bernstein, S. L., Ahmed, Z. M.,
Ness, S. L., Polomeno, R., Ramesh, A., Schloss, M., Srisailpathy, C. R. et al. (2001). Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23. Am. J. Hum. Genet.68, 26-37.
Cited by
134 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|